Each N-PORT filing of XBI compared with the one before: positions added and dropped, the largest weight changes, turnover. Computed by Mulden from the filings; dated by filing period and SEC receipt.https://themulden.com/enhttps://themulden.com/funds/xbi/https://themulden.com/funds/xbi/154 positions became 156: 13 added (2.14% of the fund), 11 dropped (5.88%). Turnover proxy 13.2%. Largest increases: SELLAS Life Sciences Group Inc 0.27% to 1.19%; Oruka Therapeutics Inc 0.5% to 1.38%; Relay Therapeutics Inc 0.38% to 1.1%; uniQure NV 0.37% to 1.03%; Dianthus Therapeutics Inc 0.66% to 1.18%; Absci Corp 0.18% to 0.56%. Largest decreases: Arcutis Biotherapeutics Inc 1.09% to 0.71%; Alkermes PLC 1.45% to 1.11%; Madrigal Pharmaceuticals Inc 1.38% to 1.06%; United Therapeutics Corp 1.24% to 0.92%; Immunome Inc 0.86% to 0.59%; Ardelyx Inc 0.62% to 0.35%. New: Avalo Therapeutics Inc (0.35%), Jade Biosciences Inc (0.32%), Solid Biosciences Inc (0.24%), Immix Biopharma Inc (0.2%), Candel Therapeutics Inc (0.19%), First Tracks Biotherapeutics Inc (0.17%). Gone: Apellis Pharmaceuticals Inc (1.83%), Amicus Therapeutics Inc (1.15%), Arcellx Inc (1.14%), Soleno Therapeutics Inc (0.67%), Day One Biopharmaceuticals Inc (0.32%), KalVista Pharmaceuticals Inc (0.29%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Fri, 28 Aug 2026 12:00:00 GMThttps://themulden.com/funds/xbi/https://themulden.com/funds/xbi/153 positions became 154: 11 added (2.09% of the fund), 10 dropped (5.37%). Turnover proxy 14.3%. Largest increases: Erasca Inc 0.1% to 1.03%; Apellis Pharmaceuticals Inc 0.91% to 1.83%; ImmunityBio Inc 0.25% to 1.06%; Apogee Therapeutics Inc 0.77% to 1.28%; Twist Bioscience Corp 0.76% to 1.16%; Cogent Biosciences Inc 0.84% to 1.22%. Largest decreases: ADMA Biologics Inc 1.13% to 0.6%; uniQure NV 0.83% to 0.37%; GRAIL Inc 1.11% to 0.72%; Amicus Therapeutics Inc 1.49% to 1.15%; Mineralys Therapeutics Inc 0.98% to 0.65%; BioMarin Pharmaceutical Inc 1.37% to 1.07%. New: Capricor Therapeutics Inc (0.48%), SELLAS Life Sciences Group Inc (0.27%), Zenas Biopharma Inc (0.24%), Vor BioPharma Inc (0.22%), Allogene Therapeutics Inc (0.17%), Hyperliquid Strategies Inc (0.17%). Gone: Avidity Biosciences Inc (1.25%), Cidara Therapeutics Inc (1.24%), Exact Sciences Corp (1.24%), Dynavax Technologies Corp (0.6%), RAPT Therapeutics Inc (0.24%), Upstream Bio Inc (0.22%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Thu, 28 May 2026 12:00:00 GMThttps://themulden.com/funds/xbi/https://themulden.com/funds/xbi/133 positions became 153: 23 added (4.21% of the fund), 3 dropped (0.81%). Turnover proxy 20.8%. Largest increases: Celcuity Inc 0.09% to 1.21%; Praxis Precision Medicines Inc 0.45% to 1.39%; Travere Therapeutics Inc 0.49% to 1.37%; Amicus Therapeutics Inc 0.67% to 1.49%; Mineralys Therapeutics Inc 0.27% to 0.98%; Mirum Pharmaceuticals Inc 0.55% to 1.22%. Largest decreases: CONTRA AKERO THERAPEUT 1.45% to 0.02%; CRISPR Therapeutics AG 2.26% to 1.12%; CONTRA METSERA INC 1.22% to 0.1%; AbbVie Inc 1.99% to 1.25%; United Therapeutics Corp 1.92% to 1.24%; Neurocrine Biosciences Inc 1.81% to 1.12%. New: Kodiak Sciences Inc (0.35%), Palvella Therapeutics Inc (0.35%), CytomX Therapeutics Inc (0.25%), Olema Pharmaceuticals Inc (0.24%), RAPT Therapeutics Inc (0.24%), Monte Rosa Therapeutics Inc (0.22%). Gone: 89bio Inc (0.63%), Arcturus Therapeutics Holdings Inc (0.15%), aTyr Pharma Inc (0.03%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Thu, 26 Feb 2026 12:00:00 GMThttps://themulden.com/funds/xbi/https://themulden.com/funds/xbi/127 positions became 133: 12 added (1.75% of the fund), 6 dropped (4.41%). Turnover proxy 16%. Largest increases: Metsera Inc 0.14% to 1.22%; CRISPR Therapeutics AG 1.41% to 2.26%; uniQure NV 0.24% to 1.09%; Avidity Biosciences Inc 0.91% to 1.71%; Summit Therapeutics Inc 1.07% to 1.58%; Revolution Medicines Inc 1.42% to 1.9%. Largest decreases: Alnylam Pharmaceuticals Inc 2.66% to 1.77%; Natera Inc 2.47% to 1.72%; Gilead Sciences Inc 2.47% to 1.75%; Insmed Inc 2.5% to 1.8%; Neurocrine Biosciences Inc 2.46% to 1.81%; Regeneron Pharmaceuticals Inc 2.46% to 1.84%. New: Cidara Therapeutics Inc (0.68%), Tango Therapeutics Inc (0.27%), Sana Biotechnology Inc (0.21%), Upstream Bio Inc (0.15%), Rezolute Inc (0.11%), Celcuity Inc (0.09%). Gone: Blueprint Medicines Corp (1.97%), SpringWorks Therapeutics Inc (1.36%), Crinetics Pharmaceuticals Inc (0.66%), Verve Therapeutics Inc (0.21%), Capricor Therapeutics Inc (0.12%), Humacyte Inc (0.1%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Wed, 26 Nov 2025 12:00:00 GMThttps://themulden.com/funds/xbi/https://themulden.com/funds/xbi/127 positions became 127: 5 added (0.64% of the fund), 5 dropped (0.52%). Turnover proxy 8.3%. Largest increases: Halozyme Therapeutics Inc 1.7% to 2.35%; Protagonist Therapeutics Inc 0.51% to 1.13%; Exelixis Inc 2.03% to 2.59%; Akero Therapeutics Inc 0.72% to 1.26%; PTC Therapeutics Inc 0.7% to 1.21%; Roivant Sciences Ltd 1.2% to 1.69%. Largest decreases: Sarepta Therapeutics Inc 1.49% to 0.64%; Madrigal Pharmaceuticals Inc 2.37% to 1.88%; Apellis Pharmaceuticals Inc 0.94% to 0.63%; Recursion Pharmaceuticals Inc 0.76% to 0.46%; Biohaven Ltd 0.69% to 0.43%; Amgen Inc 2.58% to 2.33%. New: Mineralys Therapeutics Inc (0.2%), Metsera Inc (0.14%), REGENXBIO Inc (0.13%), Verastem Inc (0.11%), Taysha Gene Therapies Inc (0.07%). Gone: Rocket Pharmaceuticals Inc (0.25%), Prothena Corp PLC (0.13%), Sana Biotechnology Inc (0.08%), Organogenesis Holdings Inc (0.03%), Scilex Holding Co (0.03%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Thu, 28 Aug 2025 12:00:00 GMThttps://themulden.com/funds/xbi/https://themulden.com/funds/xbi/141 positions became 127: 3 added (0.33% of the fund), 17 dropped (1.8%). Turnover proxy 11.3%. Largest increases: Exelixis Inc 1.26% to 2.03%; Blueprint Medicines Corp 1.39% to 2.1%; Alnylam Pharmaceuticals Inc 2.22% to 2.88%; Madrigal Pharmaceuticals Inc 1.83% to 2.37%; Vertex Pharmaceuticals Inc 2.06% to 2.53%; Bridgebio Pharma Inc 1.23% to 1.67%. Largest decreases: Vaxcyte Inc 2.16% to 1.19%; Viking Therapeutics Inc 1.95% to 1.06%; Sarepta Therapeutics Inc 2.33% to 1.49%; ADMA Biologics Inc 1.57% to 1.06%; Apellis Pharmaceuticals Inc 1.38% to 0.94%; Geron Corp 0.76% to 0.34%. New: uniQure NV (0.21%), Rigel Pharmaceuticals Inc (0.09%), Organogenesis Holdings Inc (0.03%). Gone: Avid Bioservices Inc (0.23%), Annexon Inc (0.2%), Ironwood Pharmaceuticals Inc (0.19%), Allogene Therapeutics Inc (0.14%), REGENXBIO Inc (0.13%), Tourmaline Bio Inc (0.11%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Wed, 28 May 2025 12:00:00 GMThttps://themulden.com/funds/xbi/https://themulden.com/funds/xbi/144 positions became 141: 9 added (0.94% of the fund), 12 dropped (1.43%). Turnover proxy 11.1%. Largest increases: Vaxcyte Inc 1.1% to 2.16%; Summit Therapeutics Inc 0.35% to 0.99%; TG Therapeutics Inc 1.19% to 1.78%; Apellis Pharmaceuticals Inc 0.88% to 1.38%; Scholar Rock Holding Corp 0.14% to 0.6%; Madrigal Pharmaceuticals Inc 1.41% to 1.83%. Largest decreases: Exact Sciences Corp 2.63% to 2.14%; Krystal Biotech Inc 1.25% to 0.76%; Viking Therapeutics Inc 2.4% to 1.95%; Avidity Biosciences Inc 1.37% to 0.92%; Alnylam Pharmaceuticals Inc 2.62% to 2.22%; Vertex Pharmaceuticals Inc 2.42% to 2.06%. New: Capricor Therapeutics Inc (0.31%), GRAIL Inc (0.18%), Tourmaline Bio Inc (0.11%), LENZ Therapeutics Inc (0.09%), Taysha Gene Therapies Inc (0.08%), Sangamo Therapeutics Inc (0.06%). Gone: Applied Therapeutics Inc (0.2%), Perspective Therapeutics Inc (0.2%), Sage Therapeutics Inc (0.16%), 4D Molecular Therapeutics Inc (0.15%), C4 Therapeutics Inc (0.12%), Tango Therapeutics Inc (0.12%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Thu, 27 Feb 2025 12:00:00 GMThttps://themulden.com/funds/xbi/https://themulden.com/funds/xbi/140 positions became 144: 13 added (1.57% of the fund), 9 dropped (2.26%). Turnover proxy 10.3%. Largest increases: Insmed Inc 1.09% to 2.47%; Avidity Biosciences Inc 0.65% to 1.37%; ADMA Biologics Inc 0.45% to 1.17%; Halozyme Therapeutics Inc 1% to 1.59%; Geron Corp 0.6% to 0.97%; TG Therapeutics Inc 0.87% to 1.19%. Largest decreases: Sarepta Therapeutics Inc 3.31% to 2.53%; BioMarin Pharmaceutical Inc 2.65% to 2.09%; Apellis Pharmaceuticals Inc 1.35% to 0.88%; Regeneron Pharmaceuticals Inc 2.73% to 2.3%; Cytokinetics Inc 2.06% to 1.69%; Amgen Inc 2.82% to 2.45%. New: Applied Therapeutics Inc (0.2%), Perspective Therapeutics Inc (0.2%), Emergent BioSolutions Inc (0.18%), Replimune Group Inc (0.17%), Annexon Inc (0.16%), Celcuity Inc (0.13%). Gone: Cerevel Therapeutics Holdings Inc (1.09%), Morphic Holding Inc (0.37%), Kiniksa Pharmaceuticals International Plc (0.16%), Editas Medicine Inc (0.15%), Heron Therapeutics Inc (0.13%), Cabaletta Bio Inc (0.11%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Mon, 25 Nov 2024 12:00:00 GMThttps://themulden.com/funds/xbi/https://themulden.com/funds/xbi/137 positions became 140: 13 added (2.4% of the fund), 10 dropped (4.23%). Turnover proxy 33.2%. Largest increases: Sarepta Therapeutics Inc 1.05% to 3.31%; United Therapeutics Corp 0.96% to 2.98%; Alnylam Pharmaceuticals Inc 1.01% to 2.86%; Gilead Sciences Inc 0.99% to 2.84%; Amgen Inc 1.05% to 2.82%; Regeneron Pharmaceuticals Inc 1.01% to 2.73%. Largest decreases: Altimmune Inc 0.99% to 0.21%; CONTRA INHIBRX INC 0.78% to 0.02%; C4 Therapeutics Inc 0.75% to 0.12%; Sage Therapeutics Inc 0.81% to 0.19%; Ironwood Pharmaceuticals Inc 0.98% to 0.36%; Rhythm Pharmaceuticals Inc 1.05% to 0.43%. New: Janux Therapeutics Inc (0.47%), Praxis Precision Medicines Inc (0.25%), CG oncology Inc (0.23%), Spyre Therapeutics Inc (0.23%), Immunome Inc (0.2%), Ocugen Inc (0.18%). Gone: Alpine Immune Sciences Inc (1.03%), Biomea Fusion Inc (0.79%), Replimune Group Inc (0.58%), MacroGenics Inc (0.57%), Deciphera Pharmaceuticals Inc (0.38%), Caribou Biosciences Inc (0.31%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Wed, 28 Aug 2024 12:00:00 GMThttps://themulden.com/funds/xbi/https://themulden.com/funds/xbi/123 positions became 137: 19 added (6.76% of the fund), 5 dropped (3.74%). Turnover proxy 20.9%. Largest increases: Alpine Immune Sciences Inc 0.19% to 1.03%; Dyne Therapeutics Inc 0.28% to 1.08%; Biomea Fusion Inc 0.19% to 0.79%; Kymera Therapeutics Inc 0.39% to 0.94%; Keros Therapeutics Inc 0.33% to 0.87%; Vericel Corp 0.48% to 0.99%. Largest decreases: Cytokinetics Inc 2.78% to 1.08%; CONTRA MIRATI THERAPEU 1.18% to 0.01%; ACADIA Pharmaceuticals Inc 1.7% to 0.8%; State Street Global Advisors 0.91% to 0.08%; Arrowhead Pharmaceuticals Inc 1.41% to 0.87%; Biohaven Ltd 1.47% to 0.95%. New: Altimmune Inc (0.99%), Arcutis Biotherapeutics Inc (0.9%), C4 Therapeutics Inc (0.75%), Fate Therapeutics Inc (0.59%), Apogee Therapeutics Inc (0.48%), Allogene Therapeutics Inc (0.39%). Gone: Karuna Therapeutics Inc (1.75%), ImmunoGen Inc (1.15%), uniQure NV (0.32%), RAPT Therapeutics Inc (0.29%), Bluebird Bio Inc (0.23%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Tue, 28 May 2024 12:00:00 GMThttps://themulden.com/funds/xbi/https://themulden.com/funds/xbi/135 positions became 123: 5 added (1.3% of the fund), 17 dropped (6.82%). Turnover proxy 14%. Largest increases: Cytokinetics Inc 1.06% to 2.78%; State Street Global Advisors 0.07% to 0.91%; ACADIA Pharmaceuticals Inc 1.02% to 1.7%; Karuna Therapeutics Inc 1.19% to 1.75%; Nuvalent Inc 0.64% to 1.18%; PTC Therapeutics Inc 0.68% to 1.19%. Largest decreases: Immunovant Inc 1.66% to 1.22%; Mirati Therapeutics Inc 1.58% to 1.18%; Sage Therapeutics Inc 1.23% to 0.84%; Protagonist Therapeutics Inc 0.85% to 0.49%; Bluebird Bio Inc 0.58% to 0.23%; Biomea Fusion Inc 0.47% to 0.19%. New: ImmunityBio Inc (0.47%), Soleno Therapeutics Inc (0.26%), Scholar Rock Holding Corp (0.26%), Alpine Immune Sciences Inc (0.19%), MacroGenics Inc (0.12%). Gone: Seagen Inc (1.34%), Horizon Therapeutics Plc (1.3%), Intercept Pharmaceuticals Inc (0.83%), Coherus Biosciences Inc (0.47%), Allogene Therapeutics Inc (0.36%), Seres Therapeutics Inc (0.33%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Tue, 27 Feb 2024 12:00:00 GMThttps://themulden.com/funds/xbi/https://themulden.com/funds/xbi/141 positions became 135: 7 added (2.22% of the fund), 13 dropped (4.88%). Turnover proxy 15%. Largest increases: Immunovant Inc 0.63% to 1.66%; Recursion Pharmaceuticals Inc 0.32% to 1.23%; Biohaven Ltd 0.6% to 1.3%; Mirati Therapeutics Inc 1.05% to 1.58%; Crinetics Pharmaceuticals Inc 0.33% to 0.86%; ImmunoGen Inc 0.84% to 1.31%. Largest decreases: Relay Therapeutics Inc 1.04% to 0.46%; Travere Therapeutics Inc 1.02% to 0.47%; Morphic Holding Inc 0.99% to 0.46%; Avidity Biosciences Inc 0.81% to 0.31%; Catalyst Pharmaceuticals Inc 1.27% to 0.87%; PTC Therapeutics Inc 1.04% to 0.68%. New: Coherus Biosciences Inc (0.47%), Disc Medicine Inc (0.43%), Caribou Biosciences Inc (0.35%), Vera Therapeutics Inc (0.27%), Cabaletta Bio Inc (0.26%), ACELYRIN Inc (0.26%). Gone: IVERIC bio Inc (1.14%), Chinook Therapeutics Inc (1.06%), Fate Therapeutics Inc (0.6%), Emergent BioSolutions Inc (0.57%), 2seventy bio Inc (0.31%), Enanta Pharmaceuticals Inc (0.26%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Tue, 28 Nov 2023 12:00:00 GMThttps://themulden.com/funds/xbi/https://themulden.com/funds/xbi/148 positions became 141: 4 added (0.86% of the fund), 11 dropped (3.9%). Turnover proxy 10.3%. Largest increases: Morphic Holding Inc 0.32% to 0.99%; Bridgebio Pharma Inc 0.64% to 1.18%; Protagonist Therapeutics Inc 0.51% to 1.05%; Chinook Therapeutics Inc 0.6% to 1.06%; Zentalis Pharmaceuticals Inc 0.51% to 0.94%; 89bio Inc 0.7% to 1.01%. Largest decreases: Viking Therapeutics Inc 1.29% to 0.74%; Fate Therapeutics Inc 1.14% to 0.6%; FibroGen Inc 0.66% to 0.13%; uniQure NV 0.62% to 0.3%; Arcus Biosciences Inc 1.07% to 0.81%; Scilex Holding Co 0.75% to 0.51%. New: Biomea Fusion Inc (0.4%), Aldeyra Therapeutics Inc (0.28%), Dyne Therapeutics Inc (0.17%), MiNK Therapeutics Inc (0%). Gone: Prometheus Biosciences Inc (0.91%), CTI BioPharma Corp (0.68%), Karyopharm Therapeutics Inc (0.51%), Coherus Biosciences Inc (0.39%), Altimmune Inc (0.31%), Inovio Pharmaceuticals Inc (0.27%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Mon, 28 Aug 2023 12:00:00 GMThttps://themulden.com/funds/xbi/https://themulden.com/funds/xbi/154 positions became 148: 5 added (4.2% of the fund), 11 dropped (3.97%). Turnover proxy 14.1%. Largest increases: Fate Therapeutics Inc 0.51% to 1.14%; Arcus Biosciences Inc 0.48% to 1.07%; Roivant Sciences Ltd 0.24% to 0.79%; Novavax Inc 0.6% to 1.04%; REVOLUTION Medicines Inc 0.67% to 1.02%; Replimune Group Inc 0.24% to 0.55%. Largest decreases: Madrigal Pharmaceuticals Inc 3.66% to 0.98%; Altimmune Inc 1.18% to 0.31%; Rhythm Pharmaceuticals Inc 1.06% to 0.65%; CTI BioPharma Corp 1.06% to 0.68%; Arrowhead Pharmaceuticals Inc 1.29% to 0.94%; Akero Therapeutics Inc 1.23% to 0.9%. New: Viking Therapeutics Inc (1.29%), Ardelyx Inc (1.06%), Scilex Holding Co (0.75%), 89bio Inc (0.7%), Bioxcel Therapeutics Inc (0.4%). Gone: Myovant Sciences Ltd (0.89%), Gossamer Bio Inc (0.72%), Sorrento Therapeutics Inc (0.45%), Ocugen Inc (0.38%), Design Therapeutics Inc (0.3%), ImmunityBio Inc (0.29%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Tue, 30 May 2023 12:00:00 GMThttps://themulden.com/funds/xbi/https://themulden.com/funds/xbi/155 positions became 154: 9 added (3.44% of the fund), 10 dropped (5.49%). Turnover proxy 14.5%. Largest increases: Madrigal Pharmaceuticals Inc 0.68% to 3.66%; Vaxcyte Inc 0.36% to 1.09%; Altimmune Inc 0.61% to 1.18%; Avidity Biosciences Inc 0.17% to 0.64%; Myovant Sciences Ltd 0.46% to 0.89%; Arrowhead Pharmaceuticals Inc 0.95% to 1.29%. Largest decreases: Arcus Biosciences Inc 0.95% to 0.48%; Biogen Inc 1.39% to 0.93%; Fate Therapeutics Inc 0.88% to 0.51%; Karyopharm Therapeutics Inc 0.58% to 0.28%; Sage Therapeutics Inc 1.03% to 0.75%; Sorrento Therapeutics Inc 0.73% to 0.45%. New: Akero Therapeutics Inc (1.23%), Biohaven Ltd (0.6%), Immunovant Inc (0.49%), Allakos Inc (0.33%), Roivant Sciences Ltd (0.24%), Nuvalent Inc (0.17%). Gone: Global Blood Therapeutics Inc (1.11%), ChemoCentryx Inc (1.11%), Biohaven Pharmaceutical Holding Co Ltd (1.11%), Ligand Pharmaceuticals Inc (0.5%), Heron Therapeutics Inc (0.4%), Vaxart Inc (0.36%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Tue, 28 Feb 2023 12:00:00 GMThttps://themulden.com/funds/xbi/https://themulden.com/funds/xbi/136 positions became 155: 26 added (9.78% of the fund), 7 dropped (2.26%). Turnover proxy 15.8%. Largest increases: Catalyst Pharmaceuticals Inc 0.36% to 0.83%; Prothena Corp PLC 0.6% to 1.02%; Biogen Inc 1.08% to 1.39%; CTI BioPharma Corp 0.71% to 1.01%; MannKind Corp 0.42% to 0.72%; REVOLUTION Medicines Inc 0.55% to 0.84%. Largest decreases: Novavax Inc 1.32% to 0.63%; Twist Bioscience Corp 1.37% to 0.88%; Iovance Biotherapeutics Inc 1.39% to 0.94%; Fate Therapeutics Inc 1.31% to 0.88%; PMV Pharmaceuticals Inc 0.93% to 0.55%; Global Blood Therapeutics Inc 1.48% to 1.11%. New: Rhythm Pharmaceuticals Inc (1.02%), Bluebird Bio Inc (0.98%), Verve Therapeutics Inc (0.98%), Prometheus Biosciences Inc (0.89%), Altimmune Inc (0.61%), Cogent Biosciences Inc (0.5%). Gone: Turning Point Therapeutics Inc (0.77%), Radius Health Inc (0.34%), Rigel Pharmaceuticals Inc (0.34%), Albireo Pharma Inc (0.31%), Organogenesis Holdings Inc (0.3%), Praxis Precision Medicines Inc (0.15%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Mon, 28 Nov 2022 12:00:00 GMThttps://themulden.com/funds/xbi/https://themulden.com/funds/xbi/158 positions became 136: 5 added (2.22% of the fund), 27 dropped (8.76%). Turnover proxy 15.1%. Largest increases: Amicus Therapeutics Inc 0.88% to 1.35%; Novavax Inc 0.87% to 1.32%; Seagen Inc 0.9% to 1.33%; Beam Therapeutics Inc 0.81% to 1.22%; Global Blood Therapeutics Inc 1.07% to 1.48%; Twist Bioscience Corp 0.97% to 1.37%. Largest decreases: Arcturus Therapeutics Holdings Inc 1.03% to 0.52%; Karyopharm Therapeutics Inc 0.96% to 0.57%; Heron Therapeutics Inc 0.87% to 0.58%; Ocugen Inc 1.16% to 0.86%; Vaxart Inc 0.81% to 0.51%; 2seventy bio Inc 0.6% to 0.31%. New: CRISPR Therapeutics AG (1%), CTI BioPharma Corp (0.71%), EQRx Inc (0.24%), Nkarta Inc (0.15%), Point Biopharma Global Inc (0.11%). Gone: OPKO Health Inc (0.9%), Bluebird Bio Inc (0.76%), Verve Therapeutics Inc (0.68%), C4 Therapeutics Inc (0.53%), DermTech Inc (0.52%), ALX Oncology Holdings Inc (0.43%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Fri, 26 Aug 2022 12:00:00 GMThttps://themulden.com/funds/xbi/https://themulden.com/funds/xbi/190 positions became 158: 1 added (0.27% of the fund), 33 dropped (9.6%). Turnover proxy 13.5%. Largest increases: Bridgebio Pharma Inc 0.36% to 1.02%; Karyopharm Therapeutics Inc 0.36% to 0.96%; Ocugen Inc 0.66% to 1.16%; Editas Medicine Inc 0.71% to 1.08%; Sorrento Therapeutics Inc 0.58% to 0.92%; Inovio Pharmaceuticals Inc 0.64% to 0.96%. Largest decreases: Agenus Inc 0.77% to 0.46%; Organogenesis Holdings Inc 0.52% to 0.29%; Biohaven Pharmaceutical Holding Co Ltd 1.07% to 0.86%; G1 Therapeutics Inc 0.52% to 0.31%; Myriad Genetics Inc 0.72% to 0.53%; Ideaya Biosciences Inc 0.37% to 0.2%. New: Prometheus Biosciences Inc (0.27%). Gone: Arena Pharmaceuticals Inc (1.44%), Kodiak Sciences Inc (0.79%), Invitae Corp (0.74%), Recursion Pharmaceuticals Inc (0.7%), Clovis Oncology Inc (0.53%), Gritstone bio Inc (0.5%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Fri, 27 May 2022 12:00:00 GMThttps://themulden.com/funds/xbi/https://themulden.com/funds/xbi/189 positions became 190: 14 added (4.2% of the fund), 13 dropped (5.45%). Turnover proxy 14.6%. Largest increases: Arena Pharmaceuticals Inc 0.76% to 1.44%; Protagonist Therapeutics Inc 0.3% to 0.83%; Recursion Pharmaceuticals Inc 0.38% to 0.7%; Turning Point Therapeutics Inc 0.64% to 0.93%; Biohaven Pharmaceutical Holding Co Ltd 0.78% to 1.07%; Fate Therapeutics Inc 0.66% to 0.92%. Largest decreases: Allakos Inc 0.76% to 0.1%; Seres Therapeutics Inc 0.84% to 0.4%; Bridgebio Pharma Inc 0.71% to 0.36%; CEL-SCI Corp 0.57% to 0.25%; Curis Inc 0.68% to 0.42%; Clovis Oncology Inc 0.78% to 0.53%. New: Verve Therapeutics Inc (0.78%), 2seventy bio Inc (0.68%), Gritstone bio Inc (0.5%), RAPT Therapeutics Inc (0.45%), iTeos Therapeutics Inc (0.27%), Inhibrx Inc (0.25%). Gone: Acceleron Pharma Inc (0.99%), Dicerna Pharmaceuticals Inc (0.71%), Humanigen Inc (0.65%), Cortexyme Inc (0.6%), Kadmon Holdings Inc (0.53%), Spectrum Pharmaceuticals Inc (0.37%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Fri, 25 Feb 2022 12:00:00 GMThttps://themulden.com/funds/xbi/https://themulden.com/funds/xbi/199 positions became 189: 6 added (1.16% of the fund), 16 dropped (5.93%). Turnover proxy 14.4%. Largest increases: IVERIC bio Inc 0.14% to 0.68%; Acceleron Pharma Inc 0.59% to 0.99%; Cerevel Therapeutics Holdings Inc 0.26% to 0.59%; Cytokinetics Inc 0.59% to 0.92%; CEL-SCI Corp 0.24% to 0.57%; Exelixis Inc 0.49% to 0.8%. Largest decreases: Intellia Therapeutics Inc 1.18% to 0.63%; Editas Medicine Inc 0.94% to 0.47%; MannKind Corp 0.84% to 0.53%; Beam Therapeutics Inc 0.91% to 0.61%; Forma Therapeutics Holdings Inc 0.57% to 0.29%; TCR2 Therapeutics Inc 0.38% to 0.11%. New: Recursion Pharmaceuticals Inc (0.38%), Ideaya Biosciences Inc (0.2%), VistaGen Therapeutics Inc (0.16%), Selecta Biosciences Inc (0.16%), Crinetics Pharmaceuticals Inc (0.14%), Lineage Cell Therapeutics Inc (0.12%). Gone: Translate Bio Inc (0.8%), Sesen Bio Inc (0.68%), Alexion Pharmaceuticals Inc (0.63%), Ardelyx Inc (0.51%), Esperion Therapeutics Inc (0.5%), Athenex Inc (0.45%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Fri, 26 Nov 2021 12:00:00 GMThttps://themulden.com/funds/xbi/https://themulden.com/funds/xbi/193 positions became 199: 13 added (5.54% of the fund), 7 dropped (2.11%). Turnover proxy 12.2%. Largest increases: Anavex Life Sciences Corp 0.36% to 0.92%; Applied Molecular Transport Inc 0.11% to 0.52%; Beam Therapeutics Inc 0.55% to 0.91%; Intellia Therapeutics Inc 0.84% to 1.18%; Translate Bio Inc 0.46% to 0.8%; Ocugen Inc 0.46% to 0.79%. Largest decreases: Humanigen Inc 0.81% to 0.51%; Precision BioSciences Inc 0.6% to 0.31%; Sutro Biopharma Inc 0.64% to 0.39%; VBI Vaccines Inc 0.66% to 0.41%; Vericel Corp 0.81% to 0.57%; Mersana Therapeutics Inc 0.61% to 0.38%. New: Organogenesis Holdings Inc (0.69%), Sesen Bio Inc (0.68%), Myovant Sciences Ltd (0.63%), Horizon Therapeutics Plc (0.63%), Rubius Therapeutics Inc (0.55%), Avid Bioservices Inc (0.5%). Gone: Five Prime Therapeutics Inc (0.68%), Black Diamond Therapeutics Inc (0.5%), Praxis Precision Medicines Inc (0.25%), Athersys Inc (0.23%), iTeos Therapeutics Inc (0.19%), Atreca Inc (0.14%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Mon, 23 Aug 2021 12:00:00 GMThttps://themulden.com/funds/xbi/https://themulden.com/funds/xbi/172 positions became 193: 24 added (8.91% of the fund), 3 dropped (0.89%). Turnover proxy 21%. Largest increases: Five Prime Therapeutics Inc 0.1% to 0.68%; MannKind Corp 0.23% to 0.68%; Generation Bio Co 0.13% to 0.56%; Precision BioSciences Inc 0.2% to 0.6%; ALX Oncology Holdings Inc 0.27% to 0.65%; Scholar Rock Holding Corp 0.16% to 0.5%. Largest decreases: Ionis Pharmaceuticals Inc 1.12% to 0.58%; Sage Therapeutics Inc 1.14% to 0.65%; Alexion Pharmaceuticals Inc 1.17% to 0.69%; Agios Pharmaceuticals Inc 1.17% to 0.68%; Bridgebio Pharma Inc 1.05% to 0.59%; TG Therapeutics Inc 1.12% to 0.66%. New: Humanigen Inc (0.81%), Curis Inc (0.71%), DermTech Inc (0.65%), Sutro Biopharma Inc (0.64%), Altimmune Inc (0.57%), ImmunityBio Inc (0.53%). Gone: Cardiff Oncology Inc (0.66%), Viela Bio Inc (0.23%), LENSAR Inc (0%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Fri, 28 May 2021 12:00:00 GMThttps://themulden.com/funds/xbi/https://themulden.com/funds/xbi/141 positions became 172: 41 added (12.63% of the fund), 10 dropped (6.22%). Turnover proxy 18.9%. Largest increases: Immunovant Inc 0.35% to 0.76%; REVOLUTION Medicines Inc 0.3% to 0.62%; Kura Oncology Inc 0.41% to 0.71%; Kodiak Sciences Inc 0.76% to 1.06%; Denali Therapeutics Inc 0.66% to 0.95%; Agios Pharmaceuticals Inc 0.88% to 1.17%. Largest decreases: Sorrento Therapeutics Inc 1.64% to 0.79%; Arcturus Therapeutics Holdings Inc 1.03% to 0.37%; Invitae Corp 1.24% to 0.67%; Translate Bio Inc 0.97% to 0.46%; Moderna Inc 1.11% to 0.6%; Blueprint Medicines Corp 1.3% to 0.89%. New: Seres Therapeutics Inc (0.91%), Beam Therapeutics Inc (0.86%), Seagen Inc (0.83%), Vir Biotechnology Inc (0.76%), Vaxart Inc (0.7%), Cardiff Oncology Inc (0.66%). Gone: Immunomedics Inc (1.87%), Seattle Genetics Inc (1.21%), Momenta Pharmaceuticals Inc (0.93%), Aimmune Therapeutics Inc (0.76%), Corbus Pharmaceuticals Holdings Inc (0.53%), Retrophin Inc (0.35%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Fri, 26 Feb 2021 12:00:00 GMThttps://themulden.com/funds/xbi/https://themulden.com/funds/xbi/135 positions became 141: 11 added (4.18% of the fund), 5 dropped (1.9%). Turnover proxy 12.9%. Largest increases: Sorrento Therapeutics Inc 0.78% to 1.64%; Immunomedics Inc 1.12% to 1.87%; Translate Bio Inc 0.3% to 0.97%; Mersana Therapeutics Inc 0.28% to 0.68%; Turning Point Therapeutics Inc 0.67% to 1.03%; MacroGenics Inc 0.29% to 0.62%. Largest decreases: Inovio Pharmaceuticals Inc 2.03% to 1.07%; Novavax Inc 1.79% to 1.05%; Invitae Corp 1.84% to 1.24%; Bridgebio Pharma Inc 1.12% to 0.78%; Amicus Therapeutics Inc 1.35% to 1.02%; Madrigal Pharmaceuticals Inc 0.88% to 0.58%. New: Arcturus Therapeutics Holdings Inc (1.03%), VBI Vaccines Inc (0.85%), SpringWorks Therapeutics Inc (0.37%), Immunovant Inc (0.35%), Rigel Pharmaceuticals Inc (0.3%), REVOLUTION Medicines Inc (0.3%). Gone: Principia Biopharma Inc (0.72%), Portola Pharmaceuticals Inc (0.66%), Homology Medicines Inc (0.22%), Voyager Therapeutics Inc (0.18%), State Street Global Advisors (0.12%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Fri, 27 Nov 2020 12:00:00 GMThttps://themulden.com/funds/xbi/https://themulden.com/funds/xbi/124 positions became 135: 18 added (9.48% of the fund), 7 dropped (2.5%). Turnover proxy 27.1%. Largest increases: OPKO Health Inc 0.38% to 1.35%; BioCryst Pharmaceuticals Inc 0.16% to 1.09%; Karuna Therapeutics Inc 0.09% to 0.97%; Bridgebio Pharma Inc 0.3% to 1.12%; TG Therapeutics Inc 0.49% to 1.11%; Esperion Therapeutics Inc 0.54% to 1.16%. Largest decreases: Regeneron Pharmaceuticals Inc 2.77% to 1.04%; Moderna Inc 2.65% to 1.02%; Gilead Sciences Inc 2.43% to 1.03%; Biogen Inc 2.28% to 0.94%; Vertex Pharmaceuticals Inc 2.32% to 1.06%; United Therapeutics Corp 2.26% to 1.03%. New: Inovio Pharmaceuticals Inc (2.03%), Novavax Inc (1.79%), Sorrento Therapeutics Inc (0.78%), Bioxcel Therapeutics Inc (0.76%), CEL-SCI Corp (0.52%), Constellation Pharmaceuticals Inc (0.48%). Gone: Ra Pharmaceuticals Inc (1.28%), AMAG Pharmaceuticals Inc (0.26%), Precigen Inc (0.21%), Progenics Pharmaceuticals Inc (0.21%), NextCure Inc (0.2%), Stemline Therapeutics Inc (0.18%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Thu, 27 Aug 2020 12:00:00 GMThttps://themulden.com/funds/xbi/https://themulden.com/funds/xbi/127 positions became 124: 2 added (0.21% of the fund), 5 dropped (3.74%). Turnover proxy 13.9%. Largest increases: Moderna Inc 1.36% to 2.65%; Regeneron Pharmaceuticals Inc 1.67% to 2.77%; Gilead Sciences Inc 1.66% to 2.43%; Acceleron Pharma Inc 0.63% to 1.36%; Vertex Pharmaceuticals Inc 1.68% to 2.32%; United Therapeutics Corp 1.65% to 2.26%. Largest decreases: Sage Therapeutics Inc 1.66% to 0.84%; Arrowhead Pharmaceuticals Inc 1.6% to 0.92%; Intercept Pharmaceuticals Inc 1.74% to 1.12%; Portola Pharmaceuticals Inc 0.9% to 0.34%; Bluebird Bio Inc 1.64% to 1.09%; Mirati Therapeutics Inc 1.92% to 1.46%. New: Precigen Inc (0.21%), ACHILLION PHARMACE COMMON STOCK (0%). Gone: Medicines Co/The (1.75%), ArQule Inc (0.86%), Audentes Therapeutics Inc (0.55%), Achillion Pharmaceuticals Inc (0.31%), Intrexon Corp (0.27%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Mon, 01 Jun 2020 12:00:00 GMThttps://themulden.com/funds/xbi/https://themulden.com/funds/xbi/119 positions became 127: 14 added (4.56% of the fund), 6 dropped (7.13%). Turnover proxy 13.5%. Largest increases: Apellis Pharmaceuticals Inc 0.38% to 0.92%; Deciphera Pharmaceuticals Inc 0.36% to 0.89%; Aimmune Therapeutics Inc 0.46% to 0.98%; Turning Point Therapeutics Inc 0.25% to 0.73%; Immunomedics Inc 1.08% to 1.53%; ACADIA Pharmaceuticals Inc 1.18% to 1.62%. Largest decreases: Seattle Genetics Inc 2.09% to 1.68%; CareDx Inc 1.21% to 0.83%; Arena Pharmaceuticals Inc 1.22% to 0.83%; Portola Pharmaceuticals Inc 1.2% to 0.9%; Xencor Inc 0.7% to 0.44%; FibroGen Inc 1.23% to 0.99%. New: Moderna Inc (1.36%), Clovis Oncology Inc (0.64%), Principia Biopharma Inc (0.31%), Kodiak Sciences Inc (0.31%), Bridgebio Pharma Inc (0.29%), Gossamer Bio Inc (0.29%). Gone: Celgene Corp (1.74%), Repligen Corp (1.66%), Spark Therapeutics Inc (1.59%), Genomic Health Inc (1.28%), Alder Biopharmaceuticals Inc (0.73%), CytomX Therapeutics Inc (0.13%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Thu, 27 Feb 2020 12:00:00 GMT