Each N-PORT filing of IBB compared with the one before: positions added and dropped, the largest weight changes, turnover. Computed by Mulden from the filings; dated by filing period and SEC receipt.https://themulden.com/enhttps://themulden.com/funds/ibb/https://themulden.com/funds/ibb/251 positions became 245: 2 added (1.28% of the fund), 8 dropped (3.17%). Turnover proxy 11.3%. Largest increases: Revolution Medicines, Inc. 1.54% to 2.77%; Argenx SE 3.07% to 3.75%; Vertex Pharmaceuticals, Inc. 7.44% to 8.06%; Natera, Inc. 2.41% to 2.88%; Illumina, Inc. 1.68% to 2.06%; Amgen, Inc. 7.51% to 7.81%. Largest decreases: Regeneron Pharmaceuticals, Inc. 7.21% to 4.89%; Insmed, Inc. 3.2% to 1.78%; Gilead Sciences, Inc. 7.75% to 6.82%; Alnylam Pharmaceuticals, Inc. 3.99% to 3.11%; United Therapeutics Corp. 2.3% to 1.73%; BeOne Medicines Ltd. 1.93% to 1.76%. New: Ascendis Pharma A/S (1.28%), Arcellx, Inc. (0%). Gone: Ascendis Pharma A/S (0.96%), Arcellx, Inc. (0.47%), Terns Pharmaceuticals, Inc. (0.46%), Amicus Therapeutics, Inc. (0.41%), Apellis Pharmaceuticals, Inc. (0.39%), Centessa Pharmaceuticals plc (0.25%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Tue, 25 Aug 2026 12:00:00 GMThttps://themulden.com/funds/ibb/https://themulden.com/funds/ibb/260 positions became 251: 2 added (0.26% of the fund), 11 dropped (1.45%). Turnover proxy 7.6%. Largest increases: Moderna, Inc. 0.9% to 1.68%; United Therapeutics Corp. 1.79% to 2.3%; Roivant Sciences Ltd. 0.83% to 1.24%; Revolution Medicines, Inc. 1.16% to 1.54%; Regeneron Pharmaceuticals, Inc. 6.9% to 7.21%; Vaxcyte, Inc. 0.52% to 0.75%. Largest decreases: Vertex Pharmaceuticals, Inc. 8.65% to 7.44%; Alnylam Pharmaceuticals, Inc. 4.56% to 3.99%; Amgen, Inc. 7.84% to 7.51%; Gilead Sciences, Inc. 8.07% to 7.75%; Natera, Inc. 2.66% to 2.41%; Repligen Corp. 0.77% to 0.58%. New: Definium Therapeutics, Inc. (0.16%), AtaiBeckley, Inc. (0.09%). Gone: Avidity Biosciences, Inc. (0.88%), Dynavax Technologies Corp. (0.16%), Mind Medicine MindMed, Inc. (0.11%), Atai Beckley NV (0.1%), Astria Therapeutics, Inc. (0.06%), RAPT Therapeutics, Inc. (0.05%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Thu, 28 May 2026 12:00:00 GMThttps://themulden.com/funds/ibb/https://themulden.com/funds/ibb/248 positions became 260: 41 added (2.5% of the fund), 29 dropped (9.61%). Turnover proxy 13.8%. Largest increases: Regeneron Pharmaceuticals, Inc. 5.7% to 6.9%; Vertex Pharmaceuticals, Inc. 7.66% to 8.65%; Gilead Sciences, Inc. 7.52% to 8.07%; Natera, Inc. 2.11% to 2.66%; Praxis Precision Medicines, Inc. 0.1% to 0.61%; Revolution Medicines, Inc. 0.75% to 1.16%. Largest decreases: Alnylam Pharmaceuticals, Inc. 5.68% to 4.56%; Tempus AI, Inc. 0.77% to 0.53%; BeOne Medicines Ltd. 2.11% to 1.94%; uniQure NV 0.28% to 0.12%; Halozyme Therapeutics, Inc. 0.84% to 0.69%; Legend Biotech Corp. 0.41% to 0.27%. New: Abivax SA (0.63%), Caris Life Sciences, Inc. (0.27%), Kodiak Sciences, Inc. (0.12%), Mind Medicine MindMed, Inc. (0.11%), Atai Beckley NV (0.1%), Maze Therapeutics, Inc. (0.1%). Gone: IQVIA Holdings, Inc. (3.18%), Mettler-Toledo International, Inc. (2.49%), Waters Corp. (1.77%), Merus NV (0.64%), Verona Pharma plc (0.59%), Akero Therapeutics, Inc. (0.33%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Wed, 25 Feb 2026 12:00:00 GMThttps://themulden.com/funds/ibb/https://themulden.com/funds/ibb/257 positions became 248: 1 added (0% of the fund), 10 dropped (1.59%). Turnover proxy 8.7%. Largest increases: Alnylam Pharmaceuticals, Inc. 4.77% to 5.68%; Insmed, Inc. 2.1% to 2.95%; Argenx SE 2.49% to 3.15%; BeOne Medicines Ltd. 1.59% to 2.11%; Genmab A/S 0.98% to 1.38%; United Therapeutics Corp. 1.48% to 1.82%. Largest decreases: BioNTech SE 1.87% to 0.62%; Regeneron Pharmaceuticals, Inc. 6.41% to 5.7%; Waters Corp. 2.43% to 1.77%; Natera, Inc. 2.56% to 2.11%; Mettler-Toledo International, Inc. 2.85% to 2.49%; Illumina, Inc. 1.72% to 1.41%. New: Mersana Therapeutics, Inc. (0%). Gone: Blueprint Medicines Corp. (0.94%), SpringWorks Therapeutics, Inc. (0.41%), Verve Therapeutics, Inc. (0.09%), Sage Therapeutics, Inc. (0.06%), iTeos Therapeutics, Inc. (0.04%), Inozyme Pharma, Inc. (0.02%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Wed, 26 Nov 2025 12:00:00 GMThttps://themulden.com/funds/ibb/https://themulden.com/funds/ibb/259 positions became 257: 2 added (0.01% of the fund), 4 dropped (1.51%). Turnover proxy 8.1%. Largest increases: Alnylam Pharmaceuticals, Inc. 3.72% to 4.77%; Insmed, Inc. 1.5% to 2.1%; Natera, Inc. 2.01% to 2.56%; Tempus AI, Inc. 0.33% to 0.68%; Illumina, Inc. 1.39% to 1.72%; Blueprint Medicines Corp. 0.62% to 0.94%. Largest decreases: Amgen, Inc. 8.66% to 7.44%; Regeneron Pharmaceuticals, Inc. 7.44% to 6.41%; Vertex Pharmaceuticals, Inc. 8.65% to 7.73%; Gilead Sciences, Inc. 8.39% to 7.73%; Sarepta Therapeutics, Inc. 0.64% to 0.19%; Argenx SE 2.78% to 2.49%. New: Lyell Immunopharma, Inc. (0.01%), N/A (0%). Gone: Intra-Cellular Therapies, Inc. (1.45%), 2seventy bio, Inc. (0.03%), ACELYRIN, Inc. (0.02%), Lyell Immunopharma, Inc. (0.01%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Thu, 28 Aug 2025 12:00:00 GMThttps://themulden.com/funds/ibb/https://themulden.com/funds/ibb/263 positions became 259: 0 added (0% of the fund), 4 dropped (0.1%). Turnover proxy 7.4%. Largest increases: Vertex Pharmaceuticals, Inc. 7.39% to 8.65%; Amgen, Inc. 7.92% to 8.66%; Alnylam Pharmaceuticals, Inc. 3.04% to 3.72%; Intra-Cellular Therapies, Inc. 0.84% to 1.45%; Insmed, Inc. 1.22% to 1.5%; Halozyme Therapeutics, Inc. 0.61% to 0.87%. Largest decreases: Illumina, Inc. 2.12% to 1.39%; BioNTech SE 2.15% to 1.65%; Vaxcyte, Inc. 0.99% to 0.53%; Sarepta Therapeutics, Inc. 1.09% to 0.64%; Moderna, Inc. 1.44% to 1.08%; Gilead Sciences, Inc. 8.57% to 8.39%. Gone: Poseida Therapeutics, Inc. (0.07%), Revance Therapeutics, Inc. (0.03%), Nanobiotix SA (0%), Nautilus Biotechnology, Inc. (0%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Tue, 27 May 2025 12:00:00 GMThttps://themulden.com/funds/ibb/https://themulden.com/funds/ibb/213 positions became 263: 70 added (2.72% of the fund), 20 dropped (0.54%). Turnover proxy 7.5%. Largest increases: Natera, Inc. 1.42% to 1.98%; Regeneron Pharmaceuticals, Inc. 7.21% to 7.62%; Neurocrine Biosciences, Inc. 1.1% to 1.36%; Argenx SE 2.66% to 2.91%; Scholar Rock Holding Corp. 0.05% to 0.3%; Exelixis, Inc. 0.7% to 0.94%. Largest decreases: Moderna, Inc. 2.21% to 1.44%; IQVIA Holdings, Inc. 4.13% to 3.57%; Mettler-Toledo International, Inc. 3.04% to 2.57%; Biogen, Inc. 2.7% to 2.23%; BeiGene Ltd. 1.78% to 1.41%; Alnylam Pharmaceuticals, Inc. 3.37% to 3.04%. New: Mesoblast Ltd. (0.18%), Tempus AI, Inc. (0.17%), Alvotech SA (0.15%), Praxis Precision Medicines, Inc. (0.13%), CG oncology, Inc. (0.12%), Spyre Therapeutics, Inc. (0.11%). Gone: Ligand Pharmaceuticals, Inc. (0.17%), Kiniksa Pharmaceuticals International plc (0.09%), Olink Holding AB (0.07%), Exscientia plc (0.04%), Zentalis Pharmaceuticals, Inc. (0.02%), Fulcrum Therapeutics, Inc. (0.02%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Thu, 27 Feb 2025 12:00:00 GMThttps://themulden.com/funds/ibb/https://themulden.com/funds/ibb/215 positions became 213: 1 added (0.03% of the fund), 3 dropped (0.18%). Turnover proxy 7.7%. Largest increases: BioNTech SE 1.64% to 2.32%; BeiGene Ltd. 1.16% to 1.78%; Argenx SE 2.19% to 2.66%; Vaxcyte, Inc. 0.79% to 1.18%; IQVIA Holdings, Inc. 3.76% to 4.13%; Illumina, Inc. 1.66% to 1.99%. Largest decreases: Moderna, Inc. 4.02% to 2.21%; Regeneron Pharmaceuticals, Inc. 8.36% to 7.21%; Biogen, Inc. 3.37% to 2.7%; Vertex Pharmaceuticals, Inc. 8.02% to 7.62%; Sarepta Therapeutics, Inc. 1.41% to 1.08%; BioMarin Pharmaceutical, Inc. 1.54% to 1.27%. New: Ginkgo Bioworks Holdings, Inc. (0.03%). Gone: Morphic Holding, Inc. (0.14%), Ginkgo Bioworks Holdings, Inc. (0.05%), Akouos, Inc. (0%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Tue, 26 Nov 2024 12:00:00 GMThttps://themulden.com/funds/ibb/https://themulden.com/funds/ibb/219 positions became 215: 2 added (0.07% of the fund), 6 dropped (0.54%). Turnover proxy 7.3%. Largest increases: Alnylam Pharmaceuticals, Inc. 1.84% to 3.07%; Insmed, Inc. 0.39% to 0.97%; Moderna, Inc. 3.51% to 4.02%; United Therapeutics Corp. 0.98% to 1.32%; Regeneron Pharmaceuticals, Inc. 8.03% to 8.36%; Biogen, Inc. 3.05% to 3.37%. Largest decreases: IQVIA Holdings, Inc. 4.46% to 3.76%; Illumina, Inc. 2.13% to 1.66%; Amgen, Inc. 8.37% to 7.96%; BlackRock Funds III 0.52% to 0.22%; Repligen Corp. 0.94% to 0.66%; Charles River Laboratories International, Inc. 1.34% to 1.06%. New: Kiniksa Pharmaceuticals International plc (0.07%), Fusion Pharmaceuticals, Inc. (0%). Gone: Alpine Immune Sciences, Inc. (0.17%), Inhibrx, Inc. (0.12%), Fusion Pharmaceuticals, Inc. (0.1%), Deciphera Pharmaceuticals, Inc. (0.08%), Kiniksa Pharmaceuticals Ltd. (0.07%), Achillion Pharmaceuticals, Inc. (0%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Tue, 27 Aug 2024 12:00:00 GMThttps://themulden.com/funds/ibb/https://themulden.com/funds/ibb/227 positions became 219: 1 added (0% of the fund), 9 dropped (2.65%). Turnover proxy 7.4%. Largest increases: Amgen, Inc. 7.92% to 8.37%; IQVIA Holdings, Inc. 4.01% to 4.46%; Gilead Sciences, Inc. 7.84% to 8.19%; BlackRock Funds III 0.17% to 0.52%; Argenx SE 1.63% to 1.94%; Natera, Inc. 0.69% to 0.99%. Largest decreases: Biogen, Inc. 3.73% to 3.05%; Alnylam Pharmaceuticals, Inc. 2.39% to 1.84%; Vertex Pharmaceuticals, Inc. 8.5% to 8.01%; ACADIA Pharmaceuticals, Inc. 0.51% to 0.3%; BioMarin Pharmaceutical, Inc. 1.78% to 1.59%; 10X Genomics, Inc. 0.53% to 0.36%. New: Contra Chinook Therape (0%). Gone: Karuna Therapeutics, Inc. (1.02%), ImmunoGen, Inc. (0.77%), Mirati Therapeutics, Inc. (0.38%), Cymabay Therapeutics, Inc. (0.26%), Ambrx Biopharma, Inc. (0.09%), Icosavax, Inc. (0.05%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Tue, 28 May 2024 12:00:00 GMThttps://themulden.com/funds/ibb/https://themulden.com/funds/ibb/262 positions became 227: 34 added (2.06% of the fund), 69 dropped (5.39%). Turnover proxy 10%. Largest increases: Cytokinetics, Inc. 0.27% to 0.78%; Karuna Therapeutics, Inc. 0.57% to 1.02%; ImmunoGen, Inc. 0.4% to 0.77%; IQVIA Holdings, Inc. 3.71% to 4.01%; Waters Corp. 1.68% to 1.94%; Blueprint Medicines Corp. 0.31% to 0.55%. Largest decreases: Amgen, Inc. 8.88% to 7.92%; Regeneron Pharmaceuticals, Inc. 8.43% to 7.9%; Argenx SE 2.13% to 1.63%; Gilead Sciences, Inc. 8.3% to 7.84%; Sarepta Therapeutics, Inc. 1.11% to 0.85%; Moderna, Inc. 3.55% to 3.3%. New: Biohaven Ltd. (0.3%), Fortrea Holdings, Inc. (0.23%), Dynavax Technologies Corp. (0.18%), Vericel Corp. (0.17%), Structure Therapeutics, Inc. (0.13%), MorphoSys AG (0.1%). Gone: Seagen, Inc. (4.09%), Abcam plc (0.38%), EQRx, Inc. (0.07%), Intercept Pharmaceuticals, Inc. (0.07%), Repare Therapeutics, Inc. (0.04%), Seres Therapeutics, Inc. (0.02%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Tue, 27 Feb 2024 12:00:00 GMThttps://themulden.com/funds/ibb/https://themulden.com/funds/ibb/268 positions became 262: 1 added (0% of the fund), 7 dropped (1.52%). Turnover proxy 7%. Largest increases: Regeneron Pharmaceuticals, Inc. 7.2% to 8.43%; Amgen, Inc. 8.07% to 8.88%; Seagen, Inc. 3.4% to 4.09%; Argenx SE 1.67% to 2.13%; Gilead Sciences, Inc. 8.04% to 8.3%; Neurocrine Biosciences, Inc. 0.86% to 1.12%. Largest decreases: Illumina, Inc. 2.82% to 2.25%; Apellis Pharmaceuticals, Inc. 0.83% to 0.38%; Moderna, Inc. 3.82% to 3.55%; Novocure Ltd. 0.41% to 0.16%; IQVIA Holdings, Inc. 3.95% to 3.71%; Mettler-Toledo International, Inc. 2.72% to 2.48%. New: Contra Chinook Therape (0%). Gone: IVERIC bio, Inc. (0.48%), Syneos Health, Inc. (0.41%), Reata Pharmaceuticals, Inc. (0.28%), DICE Therapeutics, Inc. (0.17%), Chinook Therapeutics, Inc. (0.17%), N/A (0%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Wed, 22 Nov 2023 12:00:00 GMThttps://themulden.com/funds/ibb/https://themulden.com/funds/ibb/271 positions became 268: 1 added (0% of the fund), 4 dropped (0.62%). Turnover proxy 6.8%. Largest increases: Vertex Pharmaceuticals, Inc. 7.65% to 8.62%; IQVIA Holdings, Inc. 3.48% to 3.95%; ImmunoGen, Inc. 0.08% to 0.39%; Legend Biotech Corp. 0.58% to 0.87%; Apellis Pharmaceuticals, Inc. 0.59% to 0.83%; Abcam plc 0.22% to 0.43%. Largest decreases: Moderna, Inc. 4.87% to 3.82%; Regeneron Pharmaceuticals, Inc. 7.99% to 7.2%; Illumina, Inc. 3.47% to 2.82%; Mettler-Toledo International, Inc. 3.16% to 2.72%; BeiGene Ltd. 1.62% to 1.3%; Waters Corp. 1.74% to 1.49%. New: Evelo Biosciences, Inc. (0%). Gone: Prometheus Biosciences, Inc. (0.36%), Provention Bio, Inc. (0.18%), BELLUS Health, Inc. (0.07%), Evelo Biosciences, Inc. (0%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Fri, 25 Aug 2023 12:00:00 GMThttps://themulden.com/funds/ibb/https://themulden.com/funds/ibb/277 positions became 271: 1 added (0% of the fund), 7 dropped (0.38%). Turnover proxy 6.6%. Largest increases: Seagen, Inc. 2.25% to 3.53%; Regeneron Pharmaceuticals, Inc. 7.07% to 7.99%; Amgen, Inc. 7.6% to 8.22%; Vertex Pharmaceuticals, Inc. 7.07% to 7.65%; Illumina, Inc. 3.03% to 3.47%; 10X Genomics, Inc. 0.3% to 0.46%. Largest decreases: Moderna, Inc. 5.68% to 4.87%; Alnylam Pharmaceuticals, Inc. 2.78% to 2.35%; BioNTech SE 2.58% to 2.21%; Halozyme Therapeutics, Inc. 0.73% to 0.49%; United Therapeutics Corp. 1.19% to 0.95%; Waters Corp. 1.94% to 1.74%. New: N/A (0%). Gone: Meridian Bioscience, Inc. (0.14%), Myovant Sciences Ltd. (0.11%), Imago Biosciences, Inc. (0.07%), Concert Pharmaceuticals, Inc. (0.03%), CinCor Pharma, Inc. (0.02%), Oyster Point Pharma, Inc. (0.01%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Fri, 26 May 2023 12:00:00 GMThttps://themulden.com/funds/ibb/https://themulden.com/funds/ibb/370 positions became 277: 22 added (1.19% of the fund), 115 dropped (2.89%). Turnover proxy 8.6%. Largest increases: Moderna, Inc. 4.1% to 5.68%; Mettler-Toledo International, Inc. 2.47% to 3.04%; BeiGene Ltd. 1.11% to 1.47%; Alnylam Pharmaceuticals, Inc. 2.46% to 2.78%; Waters Corp. 1.65% to 1.94%; Genmab A/S 1.69% to 1.98%. Largest decreases: Vertex Pharmaceuticals, Inc. 7.6% to 7.07%; Seagen, Inc. 2.56% to 2.25%; Biogen, Inc. 3.97% to 3.76%; Regeneron Pharmaceuticals, Inc. 7.26% to 7.07%; CRISPR Therapeutics AG 0.48% to 0.29%; Apellis Pharmaceuticals, Inc. 0.64% to 0.46%. New: Immunocore Holdings plc (0.18%), Ginkgo Bioworks Holdings, Inc. (0.15%), Amylyx Pharmaceuticals, Inc. (0.14%), DICE Therapeutics, Inc. (0.11%), Verona Pharma plc (0.09%), Ventyx Biosciences, Inc. (0.09%). Gone: Biohaven Pharmaceutical Holding Co. Ltd. (0.97%), Global Blood Therapeutics, Inc. (0.45%), ChemoCentryx, Inc. (0.31%), Relmada Therapeutics, Inc. (0.1%), Forma Therapeutics Holdings, Inc. (0.09%), Y-mAbs Therapeutics, Inc. (0.05%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Fri, 24 Feb 2023 12:00:00 GMThttps://themulden.com/funds/ibb/https://themulden.com/funds/ibb/374 positions became 370: 1 added (0% of the fund), 5 dropped (0.42%). Turnover proxy 7.9%. Largest increases: Biogen, Inc. 3.1% to 3.97%; Regeneron Pharmaceuticals, Inc. 6.47% to 7.26%; Alnylam Pharmaceuticals, Inc. 1.82% to 2.46%; Gilead Sciences, Inc. 7.55% to 7.94%; Sarepta Therapeutics, Inc. 0.65% to 0.94%; Karuna Therapeutics, Inc. 0.29% to 0.56%. Largest decreases: Moderna, Inc. 5.11% to 4.1%; Seagen, Inc. 3.34% to 2.56%; IQVIA Holdings, Inc. 3.99% to 3.45%; Waters Corp. 2.06% to 1.65%; BioNTech SE 2.99% to 2.62%; BeiGene Ltd. 1.38% to 1.11%. New: Syros Pharmaceuticals, Inc. (0%). Gone: Turning Point Therapeutics Inc (0.33%), Radius Health Inc (0.05%), Epizyme Inc (0.02%), Syros Pharmaceuticals Inc (0%), Chicago Mercantile Exchange (0%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Mon, 28 Nov 2022 12:00:00 GMThttps://themulden.com/funds/ibb/https://themulden.com/funds/ibb/374 positions became 374: 0 added (0% of the fund), 0 dropped (0%). Turnover proxy 7.5%. Largest increases: Vertex Pharmaceuticals Inc 6.14% to 7.47%; Seagen Inc 2.42% to 3.34%; Gilead Sciences Inc 6.93% to 7.55%; Argenx SE 1.19% to 1.69%; United Therapeutics Corp 0.74% to 1.09%; Waters Corp 1.74% to 2.06%. Largest decreases: Illumina Inc 4.16% to 3%; Amgen Inc 8.3% to 7.51%; Moderna Inc 5.57% to 5.11%; Regeneron Pharmaceuticals Inc 6.74% to 6.47%; Charles River Laboratories International Inc 1.32% to 1.12%; Mettler-Toledo International Inc 2.87% to 2.67%. Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Thu, 25 Aug 2022 12:00:00 GMThttps://themulden.com/funds/ibb/https://themulden.com/funds/ibb/376 positions became 374: 0 added (0% of the fund), 2 dropped (0.44%). Turnover proxy 8.3%. Largest increases: Vertex Pharmaceuticals Inc 4.35% to 6.14%; Regeneron Pharmaceuticals Inc 5.08% to 6.74%; Genmab A/S 1.32% to 1.76%; Incyte Corp 1.26% to 1.62%; Argenx SE 0.9% to 1.19%; BeiGene Ltd 1.02% to 1.3%. Largest decreases: Amgen Inc 9.14% to 8.3%; 10X Genomics Inc 0.96% to 0.59%; Novavax Inc 0.84% to 0.52%; Natera Inc 0.63% to 0.32%; IQVIA Holdings Inc 4.18% to 3.91%; Kodiak Sciences Inc 0.31% to 0.03%. Gone: Arena Pharmaceuticals Inc (0.44%), Tiziana Life Sciences Ltd (0%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Thu, 26 May 2022 12:00:00 GMThttps://themulden.com/funds/ibb/https://themulden.com/funds/ibb/268 positions became 376: 139 added (6.59% of the fund), 31 dropped (2.67%). Turnover proxy 13.1%. Largest increases: Amgen Inc 8.05% to 9.14%; Vertex Pharmaceuticals Inc 3.64% to 4.35%; IQVIA Holdings Inc 3.54% to 4.18%; Mettler-Toledo International Inc 2.44% to 3.01%; Illumina Inc 3.79% to 4.21%; Gilead Sciences Inc 6.82% to 7.13%. Largest decreases: Moderna Inc 8.72% to 5.82%; Biogen Inc 3.28% to 2.75%; BioNTech SE 3.58% to 3.13%; BeiGene Ltd 1.46% to 1.02%; Novavax Inc 1.19% to 0.84%; Novocure Ltd 0.81% to 0.53%. New: Syneos Health Inc (0.83%), Maravai LifeSciences Holdings Inc (0.36%), Abcam PLC (0.27%), Roivant Sciences Ltd (0.27%), Aurinia Pharmaceuticals Inc (0.2%), AbCellera Biologics Inc (0.19%). Gone: Guardant Health Inc (0.93%), Acceleron Pharma Inc (0.71%), Amyris Inc (0.19%), Kadmon Holdings Inc (0.11%), Dicerna Pharmaceuticals Inc (0.11%), Supernus Pharmaceuticals Inc (0.11%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Fri, 25 Feb 2022 12:00:00 GMThttps://themulden.com/funds/ibb/https://themulden.com/funds/ibb/274 positions became 268: 0 added (0% of the fund), 6 dropped (4.06%). Turnover proxy 10.7%. Largest increases: Moderna Inc 5.84% to 8.72%; Regeneron Pharmaceuticals Inc 4.1% to 4.82%; BioNTech SE 2.88% to 3.58%; Gilead Sciences Inc 6.27% to 6.82%; Amgen Inc 7.56% to 8.05%; Repligen Corp 0.74% to 1.15%. Largest decreases: Illumina Inc 5% to 3.79%; Novocure Ltd 1.43% to 0.81%; Biogen Inc 3.78% to 3.28%; Zai Lab Ltd 0.85% to 0.54%; BeiGene Ltd 1.67% to 1.46%; 10X Genomics Inc 1.08% to 0.92%. Gone: Alexion Pharmaceuticals Inc (2.94%), PRA Health Sciences Inc (0.78%), Translate Bio Inc (0.13%), Luminex Corp (0.12%), Constellation Pharmaceuticals Inc (0.09%), Chicago Mercantile Exchange (0%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Wed, 24 Nov 2021 12:00:00 GMThttps://themulden.com/funds/ibb/https://themulden.com/funds/ibb/282 positions became 274: 33 added (17.04% of the fund), 41 dropped (10.76%). Turnover proxy 24.8%. Largest increases: BioNTech SE 0.69% to 2.88%; Moderna Inc 4.4% to 5.84%; Genmab A/S 0.13% to 1.42%; Illumina Inc 4.71% to 5%; I-Mab 0.08% to 0.33%; Intellia Therapeutics Inc 0.46% to 0.71%. Largest decreases: Amgen Inc 9.22% to 7.56%; Vertex Pharmaceuticals Inc 4.7% to 3.79%; Gilead Sciences Inc 6.83% to 6.27%; Guardant Health Inc 1.29% to 0.82%; Vir Biotechnology Inc 0.55% to 0.22%; Bridgebio Pharma Inc 0.77% to 0.46%. New: IQVIA Holdings Inc (3.34%), Mettler-Toledo International Inc (2.31%), Waters Corp (1.54%), Novocure Ltd (1.43%), Charles River Laboratories International Inc (1.33%), Bio-Techne Corp (1.26%). Gone: AstraZeneca PLC (1.92%), Horizon Therapeutics Plc (1.73%), Royalty Pharma PLC (1.42%), Sanofi (0.85%), Jazz Pharmaceuticals PLC (0.78%), Syneos Health Inc (0.66%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Thu, 26 Aug 2021 12:00:00 GMThttps://themulden.com/funds/ibb/https://themulden.com/funds/ibb/285 positions became 282: 2 added (0.25% of the fund), 5 dropped (0.81%). Turnover proxy 8.9%. Largest increases: Amgen Inc 8.03% to 9.22%; Moderna Inc 3.5% to 4.4%; Gilead Sciences Inc 6.19% to 6.83%; BeiGene Ltd 1.04% to 1.44%; Biogen Inc 3.2% to 3.58%; Novavax Inc 0.6% to 0.97%. Largest decreases: Sarepta Therapeutics Inc 1.14% to 0.49%; Seagen Inc 2.68% to 2.12%; Vertex Pharmaceuticals Inc 5.21% to 4.7%; ACADIA Pharmaceuticals Inc 0.72% to 0.35%; Amicus Therapeutics Inc 0.51% to 0.22%; Denali Therapeutics Inc 0.85% to 0.58%. New: ImmunityBio Inc (0.22%), VYNE Therapeutics Inc (0.03%). Gone: Eidos Therapeutics Inc (0.43%), Viela Bio Inc (0.17%), NantKwest Inc (0.12%), Prevail Therapeutics Inc (0.07%), VYNE Therapeutics Inc (0.02%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Thu, 27 May 2021 12:00:00 GMThttps://themulden.com/funds/ibb/https://themulden.com/funds/ibb/209 positions became 285: 103 added (15.81% of the fund), 27 dropped (11.26%). Turnover proxy 22.5%. Largest increases: Moderna Inc 2.92% to 3.5%; Denali Therapeutics Inc 0.4% to 0.85%; Kodiak Sciences Inc 0.28% to 0.63%; Fate Therapeutics Inc 0.36% to 0.67%; CRISPR Therapeutics AG 0.61% to 0.92%; Alexion Pharmaceuticals Inc 2.62% to 2.9%. Largest decreases: Vertex Pharmaceuticals Inc 7.33% to 5.21%; Regeneron Pharmaceuticals Inc 6.05% to 4.29%; Gilead Sciences Inc 7.58% to 6.19%; Biogen Inc 3.95% to 3.2%; Alnylam Pharmaceuticals Inc 1.77% to 1.28%; Incyte Corp 2.05% to 1.62%. New: Seagen Inc (2.68%), AstraZeneca PLC (2.07%), Royalty Pharma PLC (1.65%), Novavax Inc (0.6%), BioNTech SE (0.46%), Beam Therapeutics Inc (0.4%). Gone: Seattle Genetics Inc (3.56%), Immunomedics Inc (2.06%), Novocure Ltd (1.18%), Bio-Techne Corp (1%), Mylan NV (0.8%), MyoKardia Inc (0.76%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Thu, 25 Feb 2021 12:00:00 GMThttps://themulden.com/funds/ibb/https://themulden.com/funds/ibb/210 positions became 209: 2 added (0.01% of the fund), 3 dropped (0.37%). Turnover proxy 8.4%. Largest increases: Immunomedics Inc 0.87% to 2.06%; Horizon Therapeutics Plc 1.13% to 1.77%; Novocure Ltd 0.63% to 1.18%; Biogen Inc 3.42% to 3.95%; BeiGene Ltd 0.84% to 1.31%; Seattle Genetics Inc 3.13% to 3.56%. Largest decreases: Illumina Inc 5.67% to 4.67%; BioMarin Pharmaceutical Inc 2.37% to 1.44%; Vertex Pharmaceuticals Inc 7.83% to 7.33%; Regeneron Pharmaceuticals Inc 6.55% to 6.05%; Incyte Corp 2.41% to 2.05%; Neurocrine Biosciences Inc 1.21% to 0.94%. New: Adicet Bio Inc (0.01%), RESTORBIO INC (0%). Gone: Principia Biopharma Inc (0.21%), Portola Pharmaceuticals Inc (0.15%), resTORbio Inc (0.01%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Wed, 25 Nov 2020 12:00:00 GMThttps://themulden.com/funds/ibb/https://themulden.com/funds/ibb/215 positions became 210: 1 added (0% of the fund), 6 dropped (0.97%). Turnover proxy 10.5%. Largest increases: Moderna Inc 1.36% to 2.66%; Regeneron Pharmaceuticals Inc 5.91% to 6.55%; Immunomedics Inc 0.35% to 0.87%; Seattle Genetics Inc 2.69% to 3.13%; Horizon Therapeutics Plc 0.75% to 1.13%; Inovio Pharmaceuticals Inc 0.1% to 0.45%. Largest decreases: Biogen Inc 7.66% to 3.42%; Gilead Sciences Inc 9.92% to 7.75%; Vertex Pharmaceuticals Inc 8.21% to 7.83%; Novocure Ltd 0.91% to 0.63%; Mylan NV 1.05% to 0.88%; China Biologic Products Holdings Inc 0.56% to 0.42%. New: Chicago Mercantile Exchange (0%). Gone: Forty Seven Inc (0.61%), Ra Pharmaceuticals Inc (0.31%), Progenics Pharmaceuticals Inc (0.04%), Akorn Inc (0.01%), Corium International Inc (0%), FOAMIX PHARMACEUTICALS LTD COMMON STOCK NPV (0%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Thu, 27 Aug 2020 12:00:00 GMThttps://themulden.com/funds/ibb/https://themulden.com/funds/ibb/220 positions became 215: 3 added (0.07% of the fund), 8 dropped (1.77%). Turnover proxy 10.8%. Largest increases: Gilead Sciences Inc 7.64% to 9.92%; Regeneron Pharmaceuticals Inc 4.02% to 5.91%; Vertex Pharmaceuticals Inc 6.69% to 8.21%; Biogen Inc 6.36% to 7.66%; Moderna Inc 0.78% to 1.36%; Forty Seven Inc 0.2% to 0.61%. Largest decreases: Amarin Corp PLC 0.91% to 0.19%; Amgen Inc 8.12% to 7.71%; Illumina Inc 5.79% to 5.39%; Arrowhead Pharmaceuticals Inc 0.73% to 0.37%; Allakos Inc 0.56% to 0.29%; Jazz Pharmaceuticals PLC 1.02% to 0.77%. New: Precigen Inc (0.07%), FOAMIX PHARMACEUTICALS LTD COMMON STOCK NPV (0%), ACHILLION PHARMACE COMMON STOCK (0%). Gone: Medicines Co/The (0.82%), Audentes Therapeutics Inc (0.33%), ArQule Inc (0.29%), Intrexon Corp (0.11%), Achillion Pharmaceuticals Inc (0.1%), Dermira Inc (0.1%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Mon, 01 Jun 2020 12:00:00 GMThttps://themulden.com/funds/ibb/https://themulden.com/funds/ibb/221 positions became 220: 40 added (7.94% of the fund), 41 dropped (10.52%). Turnover proxy 16.8%. Largest increases: Biogen Inc 4.37% to 6.36%; Amgen Inc 7.65% to 8.12%; Vertex Pharmaceuticals Inc 6.24% to 6.69%; Reata Pharmaceuticals Inc 0.29% to 0.68%; Arrowhead Pharmaceuticals Inc 0.4% to 0.73%; Sarepta Therapeutics Inc 0.83% to 1.16%. Largest decreases: Sage Therapeutics Inc 1.08% to 0.45%; Illumina Inc 6.4% to 5.79%; Gilead Sciences Inc 8.22% to 7.64%; Alexion Pharmaceuticals Inc 3.26% to 2.88%; Mylan NV 1.52% to 1.25%; Ionis Pharmaceuticals Inc 1.25% to 1.02%. New: Sanofi (1.25%), Guardant Health Inc (0.88%), Moderna Inc (0.78%), Bridgebio Pharma Inc (0.52%), Adaptive Biotechnologies Corp (0.45%), Axsome Therapeutics Inc (0.43%). Gone: Celgene Corp (8.46%), Spark Therapeutics Inc (0.55%), Genomic Health Inc (0.38%), Alder Biopharmaceuticals Inc (0.23%), Dova Pharmaceuticals Inc (0.12%), Replimune Group Inc (0.07%). Weights are shares of the fund's own investments, securities-lending collateral excluded; positions matched on identifiers.Thu, 27 Feb 2020 12:00:00 GMT